Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6208 | 6208-30715 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | G73S, L89V | L10I, V11VL, I13V, K20M, M36I, I62V, L63P, H69K |
| >6208-30715| codons 1-99 PQITLWQRPILTVKIGGQLMEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGKKAISTVLVGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219D | K103N, Y181C, G190A | E44D, V118I, K122E, D123E, H208Y, R211K, H221HY, L228H, V245VE, A272P, K281R, L283I, I293V, P294A, E297K, R356K, M357K, A360T, A371V |
| >6208-30715| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDDKYQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLIRGTKALTEVVALTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKKRGT HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |