Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6207 | 6207-30715 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | D67G, T215TI, K219Q | K101E, G190S | K20R, V35M, T39A, E40D, V60VI, S68G, D123E, E138A, K173E, V179I, G196E, Y232YH, D237DN, A272P, K277R, A288AT, I293V, P294A, E297R, A360T, T386I, K390R, I393M, A400T |
| >6207-30715| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICADMEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIII YQYMDDLYVSSDLEIEQHRTKIEELRQHLLRWGFITPDQKHQKEPPFLWMGHELHPNKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKTLTEVVALTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPMQKETWET |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, L90M | L33F, G73S, L89V | E34EQ, N37NI, L63P, H69K, A71LV, I93M | R57KN |
| >6207-30715| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTIFQEMILPGRWKPKMVGGIGGFMKVNQYD QIPIEICGKKVISTVLVGPTPVNIIGRNVMTQMGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |