Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6206 | 6206-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82S, I84V | L10F, V11I, L24I, L33F, G73S, L89V | I13V, K14R, M36L, N37D, K43I, Q61N, L63P, H69HN, A71V |
| >6206-30729| codons 1-99 PQITLWQRPFITVRIGGQLKEALIDTGADDTVFEELDLPGRWIPKMIGGIGGFVKVRQYD NIPIEICGNKVISTVLVGPTPSNVIGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Y115F, Q151M, M184V | A62V, V75I, F116Y, K219Q | K103N | V35IK, E53D, V118I, K122E, D123E, I135T, D177E, G196E, T200A, I202V, F214L, I244IV, A272P, K281KR, A288S, V292I, E297K, M357T, A376T |
| >6206-30729| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICTEMEKEGKISKIGPDNPYNTPV FVIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRAKVEELRQHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |