<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6206 6206-30729 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82S, I84V L10F, V11I, L24I, L33F, G73S, L89V I13V, K14R, M36L, N37D, K43I, Q61N, L63P, H69HN, A71V  
>6206-30729| codons 1-99
PQITLWQRPFITVRIGGQLKEALIDTGADDTVFEELDLPGRWIPKMIGGIGGFVKVRQYD
NIPIEICGNKVISTVLVGPTPSNVIGRNVLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, Y115F, Q151M, M184V A62V, V75I, F116Y, K219Q K103N   V35IK, E53D, V118I, K122E, D123E, I135T, D177E, G196E, T200A, I202V, F214L, I244IV, A272P, K281KR, A288S, V292I, E297K, M357T, A376T  
>6206-30729| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICTEMEKEGKISKIGPDNPYNTPV
FVIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAFYSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIEQHRAKVEELRQHLLRWGLTTPDQKHQKEPPFLWMGYELHPDKWT
VQPVVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006