Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6202 | 6202-40421 | Italy | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 38 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K103N | A98G | K20R, V35T, K43N, V60I, K64R, R83RK, V118I, K122E, I135T, A272P, I293V, E297A, T369V, T386I, K390R |
| >6202-40421| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELENEGKISKIGPENPYNTPI FAIRKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82C, I84V | G73S | L10V, I13V, I15V, L19I, K20T, M36I, I62V, L63P, A71T |
| >6202-40421| codons 1-99 PQITLWQRPVVTVKVGGQITEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKTISTVLVGPTPCNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |