<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6201 6201-30729 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I50V, I54S, V82A   L10I, E34Q, L63P, H69Y, A71I, V77I, I93L  
>6201-30729| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWKPKIIVGVGGFSKVRQYD
QIPIEICGYKIIGTVLIGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y   Y181C, G190A K101H E40F, K43Q, V118I, D123E, I142IT, R172RK, K173N, Q174K, N175Y, Q207E, R211K, L228R, Q242L, A272P, K277R, P294T, E297R, Q334L, A360IV, A376S, S379C  
>6201-30729| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEQEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFKNKYPDIVI
CQYMDDLYVASDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGV
HTNDVKQLTEAVQKISTECIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006