Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6199 | 6199-30728 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47IV, I54L, L90M | L10F, K43T, G73S | I15V, K20T, M36I, R41K, I62V, L63P, A71AITV, I72L, I85V |
| >6199-30728| codons 1-99 PQITLWQRPFVTIKVGGQLTEALLDTGADDTILEEINLPGKWTPKIVGGIGGFLKVRQYD QVPIEICGHKVLSTVLVGPTPVNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, L210W, T215Y | K219N | L100I, K103N | E44D, V60I, V118I, K122E, D123E, I135T, T200A, K223Q, L228H, V245E, A272P, K281R, I293V, E297R, D324E, M357T, A371V, S379G, K390R |
| >6199-30728| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDNKHQQEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKIATEGIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |