<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6198 6198-30728 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M A62V, K70T, V75I, F116Y K103N, G190A   P4T, V35T, K49KR, S68G, T69I, W88R, A98S, K122E, D123E, A158S, S162D, D177E, Q197QL, F214L, V245E, E248N, A272P, A288S, I293V, E297A, R356K, A376T, K390R, E399D  
>6198-30728| codons 2-399
ISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPVF
VIKRKDGITWRKLIDFRELNKRTQDFREVQLGIPHPSGLKKNKSVTVLDVGDAYYSVPLD
EEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQDSMTKILEPFRKQNPEIVIY
QYMDDLYVASDLEIGLHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIELPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTAEAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGAH
TNDVKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82C, L90M L33F, G73S L10I, T12V, G16A, R57K, I62V, L63P, A71V, I72L, V77VI, I93L  
>6198-30728| codons 1-99
PQITLWQRPIVVIKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKMIVGIGGFVKVKQYD
QVPIEICGHKVLSTVLIGPTPCNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006