Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6198 | 6198-30728 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82C, L90M | L33F, G73S | L10I, T12V, G16A, R57K, I62V, L63P, A71V, I72L, V77VI, I93L |
| >6198-30728| codons 1-99 PQITLWQRPIVVIKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKMIVGIGGFVKVKQYD QVPIEICGHKVLSTVLIGPTPCNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, K70T, V75I, F116Y | K103N, G190A | P4T, V35T, K49KR, S68G, T69I, A98S, K122E, D123E, A158S, S162D, D177E, Q197QL, F214L, V245E, E248N, A272P, A288S, I293V, E297A, R356K, A376T, K390R, E399D | W88R |
| >6198-30728| codons 2-399 ISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISRIGPENPYNTPVF VIKRKDGITWRKLIDFRELNKRTQDFREVQLGIPHPSGLKKNKSVTVLDVGDAYYSVPLD EEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPSIFQDSMTKILEPFRKQNPEIVIY QYMDDLYVASDLEIGLHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTV QPIELPNKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTAEAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGAH TNDVKQLTEAVQKITTESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |