<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6195 6195-30721 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73T T12R, I15V, G16GA, L19P, K20I, N37D, I62IV, L63P, A71V, I72IL, P79PA, I85IV, T91TS, I93L  
>6195-30721| codons 1-99
PQITLWQRPFVRIKVAGQPIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVLTTVLVGATPVNVVGRNLMSQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M, N348I K101E, G190A   K20R, T39K, K43E, V60I, V118I, K122E, I135K, S162SN, G196E, R211RK, A272P, K275KR, K277R, I293V, P294S, E297K, K311R, S322T, I329V, Q334N, I341IF, R356K, G359GS, T369V, T377L, K390R, A400AT  
>6195-30721| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI
YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVVSLTKEAE
LELAENREILREPVHGVYYDPTKDLIAEVQKQGNGQWTYQFYQEPFKILKTGKYAKMRSA
HTNDVKQLVEAVQKIALESIVIWGKTPKFRLPIQKETWET

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006