Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6195 | 6195-30721 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | T12R, I15V, G16GA, L19P, K20I, N37D, I62IV, L63P, A71V, I72IL, P79PA, I85IV, T91TS, I93L |
| >6195-30721| codons 1-99 PQITLWQRPFVRIKVAGQPIEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLTTVLVGATPVNVVGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | N348I | K101E, G190A | K20R, T39K, K43E, V60I, V118I, K122E, I135K, S162SN, G196E, R211RK, A272P, K275KR, K277R, I293V, P294S, E297K, K311R, S322T, I329V, Q334N, I341IF, R356K, G359GS, T369V, T377L, K390R, A400AT |
| >6195-30721| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICKELEEEGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVVSLTKEAE LELAENREILREPVHGVYYDPTKDLIAEVQKQGNGQWTYQFYQEPFKILKTGKYAKMRSA HTNDVKQLVEAVQKIALESIVIWGKTPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |