Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6193 | 6193-30724 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIL, I54IV, V82VA, I84IV | L10LFI, L24LI | T12P, K20KM, R41K, L63P, I64V, H69R, A71AT, T74S, I93L |
| >6193-30724| codons 1-99 PQITLWQRPIVPIKIGGQLMEALIDTGADDTVLEEMNLPGKWKPKLIGGIGGFVKVRQYD QIPVEICGRKTIGSVLVGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | V75VI | K103N | V60I, K82R, K122P, D123DE, I135T, I142T, T200TA, V245T, A272P, A288S, I293V, K347R, M357T, A376AFSV, T386TAIV, A400AT | Q197EV |
| >6193-30724| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLIDFRELNRRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DPEFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGVHRAKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFRNLKTGKYARTRGA HTNDVKQLTEAVQKIVTESIVIWGKVPKFKLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |