<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6192 6192-30724 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69DN, L210W, T215Y   L100I, K103N   K43Q, E44ED, A98S, K122E, D123E, I135T, D177E, T200A, Q207E, L228R, A272P, T286A, I293V, E297KR, D324E, Q334L, M357T, R358K, K366R, K395R, E396D  
>6192-30724| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV
FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSVPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTPDKKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQRDTWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M V11VI, G73GS L10I, I15V, G16E, K20I, M36I, N37D, I62V, L63AT, C67FL, A71V, T91TA, Q92K  
>6192-30724| codons 1-99
PQITLWQRPIITIKVEGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD
QVTIEILGHKVISTVVVGPTPANIIGRNLMAKIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006