Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6192 | 6192-30724 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69DN, L210W, T215Y | L100I, K103N | K43Q, E44ED, A98S, K122E, D123E, I135T, D177E, T200A, Q207E, L228R, A272P, T286A, I293V, E297KR, D324E, Q334L, M357T, R358K, K366R, K395R, E396D |
| >6192-30724| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLWRWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQRDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | V11VI, G73GS | L10I, I15V, G16E, K20I, M36I, N37D, I62V, L63AT, C67FL, A71V, T91TA, Q92K |
| >6192-30724| codons 1-99 PQITLWQRPIITIKVEGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD QVTIEILGHKVISTVVVGPTPANIIGRNLMAKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |