Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6190 | 6190-30723 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K101AEPQ, Y188L | K20R, V35M, K43E, E44D, V118I, D123E, E138EG, K173R, R211K, A272P, I293V, P294S, E297R, K350KR, R358K, G359S, A371V, K395KR |
| >6190-30723| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNGTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPDIVI YQYMDDLLVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVSLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMKSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73S | L19I, K20I, M36I, N37ND, L63P, H69K, A71V, I72L, I93L |
| >6190-30723| codons 1-99 PQITLWQRPFVTIKIGGQIIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGKKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |