Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6188 | 6188-30723 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_CT, L210W, T215Y | A62AV, D67S | K103N | K238T | V35T, K43Q, V118I, D123E, I135T, T139LM, S162CY, R211RK, F227FY, L228H, Q242QH, V245E, A272P, K281R, P294S, E297K, S322A, I329IV, E344D, R358K, A376AS, T386I, K390R, E399D | P140PT |
| >6188-30723| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEQEGKISKIGPENPYNTPV FVIKKKSSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNEMTGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPYHWMGYELHPDTWT VHPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVISLTKEAE LELAENREILKEPVHGVYYDPAKDLIAEVQKQGQGQWTYQIYQDPFKNLKTGKYARMKGA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47IV, I54M, I84V, L90M | V11VI, L33F, G73S, L89V | L10V, K14R, R41K, K45KR, I62V, L63P, K70KR, A71V, T74S, V77I |
| >6188-30723| codons 1-99 PQITLWQRPVITIRIGGQLKEALLDTGADDTVFEEMNLPGKWKPRMVGGIGGFMKVRQYD QVPIEICGHRVISSVLIGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |