<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6188 6188-30723 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I47IV, I54M, I84V, L90M V11VI, L33F, G73S, L89V L10V, K14R, R41K, K45KR, I62V, L63P, K70KR, A71V, T74S, V77I  
>6188-30723| codons 1-99
PQITLWQRPVITIRIGGQLKEALLDTGADDTVFEEMNLPGKWKPRMVGGIGGFMKVRQYD
QVPIEICGHRVISSVLIGPTPVNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69T_CT, L210W, T215Y A62AV, D67S K103N K238T V35T, K43Q, V118I, D123E, I135T, T139LM, S162CY, R211RK, F227FY, L228H, Q242QH, V245E, A272P, K281R, P294S, E297K, S322A, I329IV, E344D, R358K, A376AS, T386I, K390R, E399D, A400T P140PT
>6188-30723| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEQEGKISKIGPENPYNTPV
FVIKKKSSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNEMTGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPYHWMGYELHPDTWT
VHPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVISLTKEAE
LELAENREILKEPVHGVYYDPAKDLIAEVQKQGQGQWTYQIYQDPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWDT

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006