Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6186 | 6186-30723 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74I, T215F | D67G, V75A, K219Q | K103N, Y181C | K20R, V35L, K49R, S68G, V118I, K122E, I135T, M164L, E169R, K173E, I178M, T200A, R211K, F214L, D218E, T286TA, I293V, I329L, Q334E, M357T, R358K, G359S | F124Y |
| >6186-30723| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISRIGPENPYNTPV FAIKKKGGTRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDYRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSLTKILRPFREQNPDMVI CQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTKSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I50V, I54T, V82A | L10I, T12P, K14R, G16E, K20R, E34N, E35D, M36I, N37S, R41K, L63T, I64V, I85V |
| >6186-30723| codons 1-99 PQITLWQRPIVPIRIEGQLREALLDTGADDTVLNDISLPGKWKPKIIVGVGGFTKVRQYD QITVEICGHKAIGTVLVGPTPANIVGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |