<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6186 6186-30723 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48V, I50V, I54T, V82A   L10I, T12P, K14R, G16E, K20R, E34N, E35D, M36I, N37S, R41K, L63T, I64V, I85V  
>6186-30723| codons 1-99
PQITLWQRPIVPIRIEGQLREALLDTGADDTVLNDISLPGKWKPKIIVGVGGFTKVRQYD
QITVEICGHKAIGTVLVGPTPANIVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K70R, L74I, T215F D67G, V75A, K219Q K103N, Y181C   K20R, V35L, K49R, S68G, V118I, K122E, I135T, M164L, E169R, K173E, I178M, T200A, R211K, F214L, D218E, T286TA, I293V, I329L, Q334E, M357T, R358K, G359S F124Y
>6186-30723| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISRIGPENPYNTPV
FAIKKKGGTRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDYRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSLTKILRPFREQNPDMVI
CQYMDDLYVGSDLEIGQHRAKIEELRQHLLKWGLFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTKSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006