Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6185 | 6185-30723 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, F53L, G73GS | L10V, I15V, G16A, K20KMT, E34Q, K55R, L63P, A71V, I72L, Q92K |
| >6185-30723| codons 1-99 PQITLWQRPVVTIKVAGQLTEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGLVRVRQYD QIPIEICGHKVLSTVLVGPTPANIIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DN, K70R, T215F | K219Q | V60I, K104N, V118VI, K122E, I135L, E194K, G196E, I202IV, R211K, A272P, T286A, V292I, I293IV, I329V, Q334N, R358K, A371V, K395R, E399D |
| >6185-30723| codons 2-400 ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPIF AIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPLD EDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY QYMDDLYVGSDLKIEQHRTKVEELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTEEAEL ELAENREILKEPVHGVYYDPSKDLIAEVQKQGNGQWTYQIYQEPFKNLKTGKYARMKGAH TNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |