<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6185 6185-30723 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, L90M L33F, F53L, G73GS L10V, I15V, G16A, K20KMT, E34Q, K55R, L63P, A71V, I72L, Q92K  
>6185-30723| codons 1-99
PQITLWQRPVVTIKVAGQLTEALLDTGADDTVFQEMNLPGRWKPKMIGGIGGLVRVRQYD
QIPIEICGHKVLSTVLVGPTPANIIGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69DN, K70R, T215F K219Q     V60I, K104N, V118VI, K122E, I135L, E194K, G196E, I202IV, R211K, A272P, T286A, V292I, I293IV, I329V, Q334N, R358K, A371V, K395R, E399D  
>6185-30723| codons 2-400
ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPIF
AIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKNSVTVLDVGDAYFSIPLD
EDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLKIEQHRTKVEELRQHLLKWGFFTPDQKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEIVPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIAEVQKQGNGQWTYQIYQEPFKNLKTGKYARMKGAH
TNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQRETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006