Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6184 | 6184-30721 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DG, M184V, L210W, T215Y | K20R, K43KE, E44D, A98S, K102KQ, V118I, K122KE, D123E, I135T, K166R, H208HY, R211K, K223KQ, A272P, E297K, P345Q, M357T, R358K, K366KR, I375IV, T386I |
| >6184-30721| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEDGKISKIGPENPYNTPV FAIKKKNSGKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKQKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARTKGA HTNDVRQLTEAVQKVATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, I84V, L90M | L33F | L10I, T12E, I13V, G16A, K20R, M36I, N37S, R57K, L63P, A71V |
| >6184-30721| codons 1-99 PQITLWQRPIVEVKIAGQLREALLDTGADDTIFEEISLPGRWKPKIIGGIGGFIKVKQYD QIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |