Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6181 | 6181-30721 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I50V, I54A, V82A | L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92K |
| >6181-30721| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEEIDLPGRWKPKMIMGVGGFAKVRQYD QVPMEICGHKVVGTVLVGPTPANIIGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, T215Y | L100I, K103N | V108I | K20R, V35IL, T39A, K43E, E44D, D123E, I135M, E138EA, D177E, V179I, V189I, G196E, Q197K, A272P, V292I, E297K, V317A, M357T, A360V |
| >6181-30721| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSMNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIII YQYMDDLYIGSDLEIEKHRTKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |