Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6180 | 6180-30731 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GEQR, I54AV, V82A | L24I, L33LF | L10I, T12P, K14R, I15V, G16A, K20T, R41K, K55KR, L63P, A71V, I93L |
| >6180-30731| codons 1-99 PQITLWQRPIVPIRVAGQLTEALIDTGADDTVFEEMNLPGKWKPKLIRGIGGFVRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K20R, V35I, K43E, E44A, R83K, V118I, D123E, I135T, T200A, I202V, Q207E, R211K, A272P, E291D, V292I, E297K, D324E, R356K, G359S, T369V, A371AITV, I375IV, A376NS, E399D | L168LF |
| >6180-30731| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIFEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLVEVVQKVSTESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |