Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6178 | 6178-30731 | Italy | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48GV, I50V, I54V, V82T | L33F | L10V, I15V, K20R, E35D, M36I, P39PQ, R41K, R57K, Q61N, L63P, T74S, L89M, I93IL |
| >6178-30731| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTVFEDINLQGKWKPKIIVGVGGFVKVKQYD NIPIEICGHKAIGSVLVGPTPTNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74IV, M184V, T215Y | Y181C, G190A | A98G, V108VIM | S3C, K20R, V35T, E44D, K101KQ, D123E, I135V, S162C, I167IV, E169D, R172RK, K173A, Q174K, I178L, Q207E, R211K, D218E, H221HY, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, E328D, R356K, G359S, T377L, K390R, Q394L, E399D |
| >6178-30731| codons 1-399 PICPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKKKSVTMLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKVLDPFKAKNPDLVI CQYVDDLYVASDLEIGQHRTKIEELREHLLKWGFYTPEKKYQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIADIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPILKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |