<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6178 6178-30731 Italy 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, G48GV, I50V, I54V, V82T L33F L10V, I15V, K20R, E35D, M36I, P39PQ, R41K, R57K, Q61N, L63P, T74S, L89M, I93IL  
>6178-30731| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTVFEDINLQGKWKPKIIVGVGGFVKVKQYD
NIPIEICGHKAIGSVLVGPTPTNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74IV, M184V, T215Y   Y181C, G190A A98G, V108VIM S3C, K20R, V35T, E44D, K101KQ, D123E, I135V, S162C, I167IV, E169D, R172RK, K173A, Q174K, I178L, Q207E, R211K, D218E, H221HY, V245Q, E248D, A272P, K277R, T286A, E291D, V292I, I293V, E297A, E328D, R356K, G359S, T377L, K390R, Q394L, E399D  
>6178-30731| codons 1-399
PICPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLQKKKSVTMLDVGDAYFSVPL
DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKVLDPFKAKNPDLVI
CQYVDDLYVASDLEIGQHRTKIEELREHLLKWGFYTPEKKYQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIADIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPILKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006