<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6177 6177-30731 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, V11I, L33F, G73S T12TP, I15V, L19I, K20T, R41K, I62V, L63P, A71V, I72L, I85V, T91N  
>6177-30731| codons 1-99
PQITLWQRPFIPIKVGGQITEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVLSTVLVGPTPVNVVGRNLMNQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, L74V, Y115F, M184V, T215F K219Q L100I, K103N A98G V35L, V118I, K122E, I135T, T139A, G196E, T200A, I202V, E204D, F214L, L228HQ, V245M, A272P, K275KR, A288S, I293V, M357T, G359A, A376S, T386I, K390R  
>6177-30731| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAFFSIPL
DEDFRKYTAFTIPSTNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRAKVEDLRQHLLRWGLFTPDQKHQKEPPFQWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRAA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006