Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6177 | 6177-30731 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33F, G73S | T12TP, I15V, L19I, K20T, R41K, I62V, L63P, A71V, I72L, I85V, T91N |
| >6177-30731| codons 1-99 PQITLWQRPFIPIKVGGQITEALLDTGADDTVFEEMNLPGKWKPKIIGGIGGFVKVRQYD QVPIEICGHKVLSTVLVGPTPVNVVGRNLMNQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, Y115F, M184V, T215F | K219Q | L100I, K103N | A98G | V35L, V118I, K122E, I135T, T139A, G196E, T200A, I202V, E204D, F214L, L228HQ, V245M, A272P, K275KR, A288S, I293V, M357T, G359A, A376S, T386I, K390R |
| >6177-30731| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAFFSIPL DEDFRKYTAFTIPSTNNEAPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKVEDLRQHLLRWGLFTPDQKHQKEPPFQWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRAA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |