<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6174 6174-30923 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46ML, G48GV, I54V, V82VA, L90LM L24I, G73GS L10I, I15IV, M36MI, N37DH, K45KR, R57RK, I62V, L63P, A71V, V77VI, I93L L23LF
>6174-30923| codons 1-99
PQITLWQRPIVTIKVGGQLKEAFIDTGADDTVLEEIHLPGRWKPRLIVGIGGFVKVKQYD
QVPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y       T39A, K43E, E44A, A98S, V118I, I142V, K173R, Q174K, G196E, Q207E, R211A, V245E, D250E, A272P, K277R, T286P, A288APS, I293V, E297K, S322T, D324E, Q334Y, R356K, A360T, A376S, T377L, K390R, K395R, E399D  
>6174-30923| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVI
YQYMDDLYVGSDLEIEQHRTKIEELREHLWAWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKSLTEVVPLTKEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQGYGQWTYQIYQEPFKNLKTGKYAKMRGT
HTNDVKQLTEAVQKISLESIVIWGKTPKFRLPIQRETWDA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006