Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6174 | 6174-30923 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, G48GV, I54V, V82VA, L90LM | L24I, G73GS | L10I, I15IV, M36MI, N37DH, K45KR, R57RK, I62V, L63P, A71V, V77VI, I93L | L23LF |
| >6174-30923| codons 1-99 PQITLWQRPIVTIKVGGQLKEAFIDTGADDTVLEEIHLPGRWKPRLIVGIGGFVKVKQYD QVPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | T39A, K43E, E44A, A98S, V118I, I142V, K173R, Q174K, G196E, Q207E, R211A, V245E, D250E, A272P, K277R, T286P, A288APS, I293V, E297K, S322T, D324E, Q334Y, R356K, A360T, A376S, T377L, K390R, K395R, E399D |
| >6174-30923| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELREHLWAWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGPKSLTEVVPLTKEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGYGQWTYQIYQEPFKNLKTGKYAKMRGT HTNDVKQLTEAVQKISLESIVIWGKTPKFRLPIQRETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |