<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6173 6173-30724 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, V82A L10F, L33F, K43T G16GE, K20R, E35D, M36I, N37D, K55KR, R57RK, L63T, I64V, E65D, H69K, A71V  
>6173-30724| codons 1-99
PQITLWQRPFVTIKIEGQLREALLDTGADDTIFEDIDLPGRWTPKIVGGIGGFMRVKQYD
QITVDICGKKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184IV, L210W, T215Y K219R   A98G K20R, T39TA, K43E, E44A, K102KQ, S117SA, V118I, D123E, I142IT, S162SN, K166R, G196E, H208F, R211K, K223Q, V245T, E248D, A272P, K277R, K281R, V292I, I293IV, E297K, M357S, A376T, T386I, K390R G112GS, L228HY
>6173-30724| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSVTVLDVSDAYFAIPL
DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQFLWKWGFYTPDRKHQQEPPFYWMGYELHPDKWT
VQPITLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARSRGA
HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006