Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6173 | 6173-30724 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A | L10F, L33F, K43T | G16GE, K20R, E35D, M36I, N37D, K55KR, R57RK, L63T, I64V, E65D, H69K, A71V |
| >6173-30724| codons 1-99 PQITLWQRPFVTIKIEGQLREALLDTGADDTIFEDIDLPGRWTPKIVGGIGGFMRVKQYD QITVDICGKKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184IV, L210W, T215Y | K219R | A98G | K20R, T39TA, K43E, E44A, K102KQ, S117SA, V118I, D123E, I142IT, S162SN, K166R, G196E, H208F, R211K, K223Q, V245T, E248D, A272P, K277R, K281R, V292I, I293IV, E297K, M357S, A376T, T386I, K390R, A400T | G112GS, L228HY |
| >6173-30724| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSVTVLDVSDAYFAIPL DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQFLWKWGFYTPDRKHQQEPPFYWMGYELHPDKWT VQPITLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARSRGA HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |