Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6171 | 6171-30724 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, V11I, G73T, L89V | I13IV, L19Q, K20I, R41RK, L63P, A71V, P79A, I85IV, I93IL |
| >6171-30724| codons 1-99 PQITLWQRPFITVKIGGQQIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFMKVRQYD QIPIEICGHKVITTVLVGATPVNVVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, L210W, T215Y | K11KR, V35M, T39A, K43E, R83K, D123E, T139V, Q145V, K166R, D177E, G196E, H208Y, R211K, K249KR, A272P, I274IV, A288S, I293V, E297K, T338S, K390R |
| >6171-30724| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNEVPGIRYVYNVLPMGWKGSPAIFQSSMTRILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPERDSWTVNDIQKLVGKLNWASQIYPGVKVKQLCKLLRGTKSLTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWSYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |