Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6166 | 6166-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | V11VI, L33I, G73GS, N83D, L89V | L10I, I13V, L19LV, K20R, A22V, E35D, M36I, N37E, I62IV, L63P, A71AITV, Q92QK |
| >6166-30729| codons 1-99 PQITLWQRPIITVKIGGQVREVLLDTGADDTVIEDIELPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKVISTVLVGPTPVDVIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K101PQ, K103N | V35K, T39A, K43N, V118I, K122E, I142V, E203K, Q207E, R211K, L228N, A288S, I293IV, I326IV, Q334D, M357T, A360I |
| >6166-30729| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAELENEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDKKHQKEPPFNWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGDGQWTYQIYQEPFKNLKTGKYARTRGI HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |