Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6165 | 6165-30903 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10F, L24I, L33I | I13IV, K20KR, E35D, M36I, R41RK, L63P, I64V |
| >6165-30903| codons 1-99 PQITLWQRPFVTVKIGGQLREALIDTGADDTVIEDINLPGKWKPKMIGGIGGFVKVRQYD QIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103KN | K20R, V35L, T39K, K43E, E44D, S68G, K122E, D123DG, I135IT, T200K, Q207E, R211K, A272P, K281R, I293V, P294Q, S322T, D324E, G333E, G335GC, R356K, K366R, A371V, K390R |
| >6165-30903| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICKELEEDGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRKKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVQLTEEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQEQCQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |