<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6165 6165-30903 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L10F, L24I, L33I I13IV, K20KR, E35D, M36I, R41RK, L63P, I64V  
>6165-30903| codons 1-99
PQITLWQRPFVTVKIGGQLREALIDTGADDTVIEDINLPGKWKPKMIGGIGGFVKVRQYD
QIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W, T215Y   K103KN   K20R, V35L, T39K, K43E, E44D, S68G, K122E, D123DG, I135IT, T200K, Q207E, R211K, A272P, K281R, I293V, P294Q, S322T, D324E, G333E, G335GC, R356K, K366R, A371V, K390R  
>6165-30903| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICKELEEDGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRKKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKALTEVVQLTEEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQEQCQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006