<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6163 6163-30729 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82A, L90M K43T, F53L L10V, I15IV, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, A71V, V77I, I93L  
>6163-30729| codons 1-99
PQITLWQRPVVTIKVGGQIREALLDTGADDTVLEDVELPGRWTPKIVGGIGGLVKVKQYD
QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, T215Y   K103N   K43KE, V118I, K122E, I135L, S162C, T200K, L228H, V245E, A272P, K277R, Q278H, K281R, I293V, P294Q, S322T, D324E, G333GE, Q334H, R356K, K366R, A376AT, T386TAIV, K390R, E399D  
>6163-30729| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRKKIEELRQHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCRLLRGTKALTEVVQLTEEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRGA
HTNDVRQLTEAVQKITTESIVIWGKVPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006