Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6163 | 6163-30729 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | K43T, F53L | L10V, I15IV, L19I, K20R, E35D, M36V, N37E, R57K, I62V, L63P, A71V, V77I, I93L |
| >6163-30729| codons 1-99 PQITLWQRPVVTIKVGGQIREALLDTGADDTVLEDVELPGRWTPKIVGGIGGLVKVKQYD QVPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K103N | K43KE, V118I, K122E, I135L, S162C, T200K, L228H, V245E, A272P, K277R, Q278H, K281R, I293V, P294Q, S322T, D324E, G333GE, Q334H, R356K, K366R, A376AT, T386TAIV, K390R, E399D |
| >6163-30729| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRKKIEELRQHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRHLCRLLRGTKALTEVVQLTEEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVRQLTEAVQKITTESIVIWGKVPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |