Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6162 | 6162-30903 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K103S, G190A | V35I, K43E, E44A, V60I, E79D, K82R, R83K, V118I, K122E, I135T, K166R, D177DN, V179VI, G196E, E203D, Q207E, H208Y, R211K, A272P, K277R, E297K, D324DE, G335S, M357R, S379C, K390R, Q394T, K395R |
| >6162-30903| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRDLNRKTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIII YQYVDDLYVASDLEIEQHRTKIDELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARRRGA HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPITRETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82A, L90M | L33LF | L10IV, K20R, E34Q, E35D, M36I, N37DE, D60DE, I62IV, L63P, H69K, A71V, T91S, I93L, C95F |
| >6162-30903| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVFQDIELPGRWKPKMIVGIGGFSKVRQYE QVPIEICGKKVIGTVLVGPTPANIIGRNLMSQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |