<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6162 6162-30903 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54S, V82A, L90M L33LF L10IV, K20R, E34Q, E35D, M36I, N37DE, D60DE, I62IV, L63P, H69K, A71V, T91S, I93L, C95F  
>6162-30903| codons 1-99
PQITLWQRPVVTIKIGGQLREALLDTGADDTVFQDIELPGRWKPKMIVGIGGFSKVRQYE
QVPIEICGKKVIGTVLVGPTPANIIGRNLMSQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, V75M, M184V, L210W, T215Y   K103S, G190A   V35I, K43E, E44A, V60I, E79D, K82R, R83K, V118I, K122E, I135T, K166R, D177DN, V179VI, G196E, E203D, Q207E, H208Y, R211K, A272P, K277R, E297K, D324DE, G335S, M357R, S379C, K390R, Q394T, K395R  
>6162-30903| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRDLNRKTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIII
YQYVDDLYVASDLEIEQHRTKIDELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARRRGA
HTNDVKQLTEAVQKIATECIVIWGKTPKFRLPITRETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006