Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6160 | 6160-30710 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, T215F | D67DG | K101KE | K11KR, E28K, V35T, D123E, I135T, V179I, I180IV, R211K, A272P, K277R, P294PT, E297R, R356RK, A360AV, T369TA, A376T, T377L, K390R |
| >6160-30710| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTKEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKGSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIIV YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRGV HTNDVKQLAEAVQKITLESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L10F, N88D | I15V, G16E, K20M, N37S, Q61H, L63S, H69K, V77I, P79A |
| >6160-30710| codons 1-99 PQITLWQRPFVTIKVEGQLMEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFIKVRQYD HISIEICGKKAIGTVLIGATPVNVIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |