Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6158 | 6158-30704 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54S, V82A | L33F, Q58E | Q7QE, L10I, G16A, L19I, E34Q, L63T, A71V, I72T, T74S, V77I, I93L |
| >6158-30704| codons 1-99 PQITLWERPIVTIKIAGQIKEALLDTGADDTVFQEMNLPGRWKPKMIVGVGGFSKVREYD QITIEICGHKVTGSVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | V75I, K219Q | L100I, K103N | A98G | I2IV, K20R, T39TA, V118I, K122P, I135T, D177E, I202V, F214L, D218E, A272P, T286A, E297K, V317A, K350R, R356K, G359S, A371V, A376AS, T377L |
| >6158-30704| codons 1-399 PVSPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLIDFRELNKRTQDFWEVQLGIPHPGGIKKNKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLTEVVQKISLESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |