Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6157 | 6157-30704 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48A, I54V, V82A, I84V, L90M | L33F, Q58E, G73GS, L89LV | T4S, L10I, K20R, E35D, M36L, R57RK, I62V, L63P, A71V, I72ILM, Q92K |
| >6157-30704| codons 1-99 PQISLWQRPIVTIKIGGQLREALLDTGADDTVFEDLNLPGRWKPKMIAGIGGFVKVKEYD QVPIEICGHKVMSTVLVGPTPANVIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M | A62V, K70KT, V75I, F116Y | Y181C, G190A | E138K | I2V, P4T, S68G, T69TI, V118I, D121H, K122E, I135V, S162C, R172RK, D177E, T200TA, E203D, Q207A, F214L, H221Y, L228R, V245I, A272P, T286A, I293V, I326V, Q334L, T386I | V179GS |
| >6157-30704| codons 1-400 PVSTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKRKDGITWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFYSIPL HEDFRKYTAFTIPSVNNKTPGIRYQYNVLPMGWKGSPAIFQCSMTKILEPFKKQNPEISI CQYMDDLYVASDLEIGQHRAKIDELRAHLLRWGLTTPDKKYQKEPPFRWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |