<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6156 6156-30701 Italy 2003 HIV1 F Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A   L10I, T12K, I15V, G16A, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, I93L  
>6156-30701| codons 1-99
PQITLWQRPIVKIKVAGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYD
NITIDICGHKATGAVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, T215F K219E, N348I Y181YC Y318YF V35KR, T39A, V106I, K122E, I135T, S162C, K173T, Q174K, T200A, E203K, Q207E, H208Y, R211Q, K223KQ, L228H, V245Q, A272P, E291D, V292I, I293V, E297A, I341F, R356K, G359S, T377L, K390R, Q394L  
>6156-30701| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDIVI
CQYVDDLYVGSDLEIGQHRAKIKELREYLLQWGFFTPDEKHQQEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTAEAE
LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYAKMRSA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPILKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006