Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6156 | 6156-30701 | Italy | 2003 | HIV1 | F | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, T12K, I15V, G16A, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T, T74A, I93L |
| >6156-30701| codons 1-99 PQITLWQRPIVKIKVAGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFVKVKQYD NITIDICGHKATGAVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, T215F | K219E, N348I | Y181YC | Y318YF | V35KR, T39A, V106I, K122E, I135T, S162C, K173T, Q174K, T200A, E203K, Q207E, H208Y, R211Q, K223KQ, L228H, V245Q, A272P, E291D, V292I, I293V, E297A, I341F, R356K, G359S, T377L, K390R, Q394L |
| >6156-30701| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRTKNPDIVI CQYVDDLYVGSDLEIGQHRAKIKELREYLLQWGFFTPDEKHQQEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDIVPLTAEAE LELAENREILKEPVHGVFYDPSKDLIAEIQKQGQGQWTYQFYQEPFKILKTGKYAKMRSA HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPILKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |