<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6153 6153-30826 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L10F, V11I, K43KT T12P, I15V, G16GA, L19T, K20I, E35D, M36I, L63P, A71I, T74S, I93IL  
>6153-30826| codons 1-99
PQITLWQRPFIPIKVAGQTIEALLDTGADDTVLEDINLPGRWTPKIIGGVGGFVKVRQYD
QIPIEICGHKIIGSVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75VIM, L210W, T215Y K219R     K43Q, E44ED, V60I, V118I, K122E, I135T, V179VIM, Q207E, H208HY, D218E, E224K, A272S, T286A, I293V, V317A, S322T, Q334S, G359S, A371V, T386TI, K390R  
>6153-30826| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIMI
YQYMDDLYVGSDLEIGQHRTKIEELREYLWRWGFYTPERKHQKKPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGAYYDPTKDLIAEIQKQGSGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006