Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6152 | 6152-30826 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219KR | G190A | K101HQ | V35M, K43N, E44D, V118I, K122E, D123E, I135IV, S162SDGN, K166KQR, V179VI, H208HY, R211K, L228H, A272P, K277R, K281R, I293V, E297KR, M357T, K366R, A376T, T386M |
| >6152-30826| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIII YQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVRQLTEAVQKITTESIVIWGKMPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, K43T | L10I, I15IV, Q18QH, K55R, R57K, L63P, A71V, I72IM, Q92QK |
| >6152-30826| codons 1-99 PQITLWQRPIVTIKVGGHLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVRVKQYD QIPIEICGHKVMGTVLVGPTPANIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |