<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6152 6152-30826 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L24I, K43T L10I, I15IV, Q18QH, K55R, R57K, L63P, A71V, I72IM, Q92QK  
>6152-30826| codons 1-99
PQITLWQRPIVTIKVGGHLKEALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVRVKQYD
QIPIEICGHKVMGTVLVGPTPANIIGRNLLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219KR G190A K101HQ V35M, K43N, E44D, V118I, K122E, D123E, I135IV, S162SDGN, K166KQR, V179VI, H208HY, R211K, L228H, A272P, K277R, K281R, I293V, E297KR, M357T, K366R, A376T, T386M  
>6152-30826| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPDIII
YQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPDRKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNDVRQLTEAVQKITTESIVIWGKMPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006