Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6151 | 6151-30910 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82T, I84V | Q58E | L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64V, I66F, A71V |
| >6151-30910| codons 1-99 PQITLWQRPIVTIKIGGQIREALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVKVREYD QVPVEFCGHKVIGTVVVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | A62V, D67G, K219N | K22R, K43KR, E44D, S68G, V118I, D123E, I135T, S162SR, R211K, V245K, K277R, E291ED, V317A, Q334L, G359S, T386I, K390R |
| >6151-30910| codons 1-399 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALVEICTELERDGKISKIGPENPYNTPV FVIKKKGGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQRSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTDVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |