Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6150 | 6150-30826 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67~, K70R, L74V, M184V | A62V, T215I, K219E | K11KR, V35I, K43E, T69N, A98S, K122KE, D123E, I135V, S162A, V179VI, R211K, L228H, A272P, K275R, K277R, T286A, P313T, V314I, M357T, T369V, T386TI, K390R |
| >6150-30826| codons 1-399 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALIEICTEMEEEGKISKIGPENPYNTPV FVIKKK~SNRWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGFITPDEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKETIHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48V, I54ST, V82A, I84V | L33F, K43T, Q58QE | L10I, T12S, I13V, K14R, L19T, D60E, Q61E, L63P, H69HY, A71V, V77I, I93L |
| >6150-30826| codons 1-99 PQITLWQRPIVSVRIGGQTKEALLDTGADDTVFEEMNLPGRWTPKIIVGIGGFTKVREYE EIPIEICGYKVIGTVLIGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |