<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6141 6141-30909 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q Y181C, Y188L   K20R, K32E, V35L, E36K, K43Q, V106I, T107S, L109V, D123E, I135T, I167V, R172K, D177E, I178L, V189I, T200A, I202V, E204ED, H208Y, R211A, D218E, L228H, V245E, A272P, V292VI, I293V, E297K, G335D, R356K, G359N, A371T, T377M, I382T, T386I  
>6141-30909| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIEALLKICTEMEQEGKISKIGPENPYNTPV
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSISVVDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFKKQNPELVI
CQYMDDLLIGSDLEIGQHRAKVEDLRQYLLAWGFFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRNA
HTNDVKQLTETVQKIAMESIVTWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M V11I, T74P, L89V L10I, I15V, G16AE, L19P, K20IV, M36I, R41K, I62V, L63H, H69R, K70E, I72V, G73V, I85V  
>6141-30909| codons 1-99
PQITLWQRPIITIKVEGQPVEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFVKVRQYD
QVHIEICGREAVVPVLVGPTPVNVVGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006