Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6141 | 6141-30909 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | V11I, T74P, L89V | L10I, I15V, G16AE, L19P, K20IV, M36I, R41K, I62V, L63H, H69R, K70E, I72V, G73V, I85V |
| >6141-30909| codons 1-99 PQITLWQRPIITIKVEGQPVEALLDTGADDTVLEEINLPGKWKPKIVGGIGGFVKVRQYD QVHIEICGREAVVPVLVGPTPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | Y181C, Y188L | K20R, K32E, V35L, E36K, K43Q, V106I, T107S, L109V, D123E, I135T, I167V, R172K, D177E, I178L, V189I, T200A, I202V, E204ED, H208Y, R211A, D218E, L228H, V245E, A272P, V292VI, I293V, E297K, G335D, R356K, G359N, A371T, T377M, I382T, T386I |
| >6141-30909| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIEALLKICTEMEQEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSISVVDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKVLEPFKKQNPELVI CQYMDDLLIGSDLEIGQHRAKVEDLRQYLLAWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKMRNA HTNDVKQLTETVQKIAMESIVTWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |