Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6140 | 6140-30904 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215Y | V75S, K219E | K101E, Y181C | K20R, T39A, L109I, K122E, D123E, T200I, R211K, D218E, F227Y, A272P, I293V, P294Q, E297A, E344ED, G359S, T369V, A371V, A376V, T386I |
| >6140-30904| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKVSDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVIDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRIKIEELRQHLLKWGFYTPEEKHQKEPPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVQLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQDPFKNLKTGKYARMRSA HTNDVKQLVEVVQKIVTESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E, G73GS | T4TP, L10V, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, A71V, I93L | T91TK |
| >6140-30904| codons 1-99 PQIPLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVREYE EVPIEICGHKVISTVLVGPTPANIIGRNLMKQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |