<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6140 6140-30904 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, M184V, T215Y V75S, K219E K101E, Y181C   K20R, T39A, L109I, K122E, D123E, T200I, R211K, D218E, F227Y, A272P, I293V, P294Q, E297A, E344ED, G359S, T369V, A371V, A376V, T386I  
>6140-30904| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSTRWRKVSDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVIDVGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRIKIEELRQHLLKWGFYTPEEKHQKEPPYLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVQLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQDPFKNLKTGKYARMRSA
HTNDVKQLVEVVQKIVTESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M Q58E, G73GS T4TP, L10V, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, A71V, I93L T91TK
>6140-30904| codons 1-99
PQIPLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVREYE
EVPIEICGHKVISTVLVGPTPANIIGRNLMKQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006