Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6138 | 6138-30626 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | D67G, K70T | L100I, K103N | K20R, T39E, E44D, K49R, V60I, S68SR, V118I, D123N, I135T, S162D, D177E, V179I, I202V, Q207E, R211K, V245E, A272P, T286A, A288S, E297A, E312T, R356K, M357T |
| >6138-30626| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICEELEKDGKISRIGPENPYNTPI FAIKKKGRTTWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKNFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPEIII YQYMDDLYVGSDLEIGQHRTKVEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEVIPLTAEAE LELAENREILKTPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48V, I50V, I54A, V82A | L10I, N37ND, F53FY, R57K, I62V, L63A, I64M, A71V, I72IV, I93L |
| >6138-30626| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIVGVGGYAKVKQYD QVAMEICGHKVVGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |