Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6137 | 6137-30610 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75IT, M184MV, T215F | K219E | K101E, Y181C, G190A | K20R, V21I, K43KR, V106VI, V118I, I135R, N175NH, V179I, F214L, K223T, L228H, A272P, K277R, I326V, Q334L, G359S, A371V |
| >6137-30610| codons 1-400 PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEREGKISKIGPENPYNTPV FAIKKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQHPDIII CQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLFTPDEKHQTEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54A, V82A | L24I | L10I, T12P, K14R, I15V, K20R, E35D, M36I, N37D, L63P, A71V |
| >6137-30610| codons 1-99 PQITLWQRPIVPIRVGGQLREALIDTGADDTVLEDIDLPGRWKPKLIGGIGGFAKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |