<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6137 6137-30610 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54A, V82A L24I L10I, T12P, K14R, I15V, K20R, E35D, M36I, N37D, L63P, A71V  
>6137-30610| codons 1-99
PQITLWQRPIVPIRVGGQLREALIDTGADDTVLEDIDLPGRWKPKLIGGIGGFAKVRQYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, V75IT, M184MV, T215F K219E K101E, Y181C, G190A   K20R, V21I, K43KR, V106VI, V118I, I135R, N175NH, V179I, F214L, K223T, L228H, A272P, K277R, I326V, Q334L, G359S, A371V  
>6137-30610| codons 1-400
PISPIETVPVKLKPGMDGPRIKQWPLTEEKIKALVEICTELEREGKISKIGPENPYNTPV
FAIKKKNSTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSIPL
DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQHPDIII
CQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLFTPDEKHQTEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006