Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6136 | 6136-30924 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47IV, I54M, V82A, L90M | V11VI, K43T, L89V | L10I, I15V, G16A, N37D, L63C, A71V, I72M, G73D, I85V, Q92K |
| >6136-30924| codons 1-99 PQITLWQRPIITIKVAGQLKEALLDTGADDTILEEMDLPGRWTPKLVGGIGGFMKVRQYD QICIEICGHKVMDTVLVGPTPANIVGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K20R, K43E, E44A, V118I, K122E, I135V, T139M, S162C, E203EK, Q207E, H208Y, K223KE, K277R, A288S, I293V, E297A, R358K, G359S, A360T, K366R, T386I, E399D |
| >6136-30924| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNEMPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREYLWRWGFYTPDNKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKST HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |