<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6135 6135-30904 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y V75T, K219N K101E, Y181C, G190A V108I K20R, V35M, K43Q, I94L, K103KR, V118I, D123E, I135L, T165I, K166Q, G196E, R211K, D218E, A272P, T286A, E297K, D324E, I329IV, R356K, G359S, V365I, A371V, A376S, K390R  
>6135-30904| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGLPHPAGLEKRKSVTILDVGDAYFSIPL
DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMIQILEPFRKQNPDIVI
CQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDIKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54M, I84V, L90M L33F, G73T, L89V L10I, I13V, I62V, L63P, I66F, H69N, A71L, I72T, V77I  
>6135-30904| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKMVGGIGGFMKVRQYD
QVPIEFCGNKLTTTVLIGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006