Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6135 | 6135-30904 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54M, I84V, L90M | L33F, G73T, L89V | L10I, I13V, I62V, L63P, I66F, H69N, A71L, I72T, V77I |
| >6135-30904| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWKPKMVGGIGGFMKVRQYD QVPIEFCGNKLTTTVLIGPTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | V108I | K20R, V35M, K43Q, I94L, K103KR, V118I, D123E, I135L, T165I, K166Q, G196E, R211K, D218E, A272P, T286A, E297K, D324E, I329IV, R356K, G359S, V365I, A371V, A376S, K390R |
| >6135-30904| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEQEGKISKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGLPHPAGLEKRKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMIQILEPFRKQNPDIVI CQYVDDLYVASDLEIEQHRTKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDIKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |