Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-6131 | 6131-30624 | Italy | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, M184V, L210W, T215Y | K219R | L100I, K103N | T39A, E44D, V118I, D123E, I135T, T139K, S162C, S163C, V179T, T200A, E203K, Q207E, H208HY, R211K, K223E, L228H, A272P, K277R, L283I, I293V, R356K, G359S, A371V, K390R | I142NS |
| >6131-30624| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNEKPGSRYQYNVLPQGWKGSPAIFQCCMTKILEPFRKQNPDITI YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDRKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48A, I54V, V82A | L24I, L33F, K43T, G73S | L10I, I13V, I15V, L19I, K20T, M36L, N37D, R41RK, L63P, A71V, Q92K |
| >6131-30624| codons 1-99 PQITLWQRPIVTVKVGGQITEALIDTGADDTVFEELDLPGKWTPKLIAGIGGFVKVRQYD QIPIEICGHKVISTVLVGPTPANIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |