<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-6131 6131-30624 Italy 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48A, I54V, V82A L24I, L33F, K43T, G73S L10I, I13V, I15V, L19I, K20T, M36L, N37D, R41RK, L63P, A71V, Q92K  
>6131-30624| codons 1-99
PQITLWQRPIVTVKVGGQITEALIDTGADDTVFEELDLPGKWTPKLIAGIGGFVKVRQYD
QIPIEICGHKVISTVLVGPTPANIIGRNLLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, M184V, L210W, T215Y K219R L100I, K103N   T39A, E44D, V118I, D123E, I135T, T139K, I142NS, S162C, S163C, V179T, T200A, E203K, Q207E, H208HY, R211K, K223E, L228H, A272P, K277R, L283I, I293V, R356K, G359S, A371V, K390R  
>6131-30624| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNEKPGSRYQYNVLPQGWKGSPAIFQCCMTKILEPFRKQNPDITI
YQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTPDRKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006